Synthesis of stimuli-sensitive copolymers by RAFT polymerization: potential candidates as drug delivery systems
نویسندگان
چکیده
منابع مشابه
Stimuli Sensitive Hydrogels in Drug Delivery Systems
Hydrogels are the 3 dimensional cross linked polymeric networks which absorb the water 10-20 times of its molecular weight. Hydrogels are sensitive to different environmental stimuli like pH, temperature, ion, electric signals, light, pressure, antigen specific, enzyme sensitive, and glucose levels. When the environment is get change they get swell, and swelling is the most important characteri...
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Purpose: Enalapril maleate (EPM), was used for hypertension and congestive heart failure. In this way, an innovative delivery system with mPEG–PCL was synthesized and the release profile of the EPM from the drug-loaded polymersomes was evaluated. Methods: Di-block methoxy)-poly (ethylene glycol) - Poly (caprolactone) (mPEG-PCL) copolymers were synthesized and used to prepare of polymersom...
متن کاملBlock copolymers containing organic semiconductor segments by RAFT polymerization.
Approaches to the synthesis of block copolymers containing organic semiconductor segments (polythiophene, perylene diimide) by RAFT polymerization have been explored. A method involving transformation of a vinyl derivative to a macro-RAFT agent provides for the synthesis of block copolymers which are joined by a short non-hydrolysable linkage.
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The development of stimuli-sensitive release systems for protein and peptide delivery has been a subject of significant pharmaceutical importance in recent years, especially in relation to the possible development of intelligent delivery systems. In this review we concentrate on biological and chemical characteristics of these systems and we identify important guidelines as well as unsolved pro...
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Vacuum dried Metronidazole hydrochloride (MTZ) loaded Crosslinked polymeric blend of Poly(vinyl)alcohol (PVA) and Gelatin(GE) in different ratios by 30 freeze/thaw cycles (FTC) tested for stimuli sensitivity and crosslinking at various pH, temperature, ionic concentration and oscillatory test along with dye absorption test showed maximum swelling in alkaline pH and decreased swelling with incre...
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ژورنال
عنوان ژورنال: Materials Research
سال: 2014
ISSN: 1980-5373,1516-1439
DOI: 10.1590/s1516-14392014005000033